Sooner or later, no matter how healthy a man is, age-related changes occur with him. Each individual has its own period of onset of change. Typically, this is an average age of about 40 years, but it can begin sooner or later depending on the health status of the man and the lifestyle that he leads. Next, we will try to answer the exciting questions of hormonal therapy, and talk about the types of hormonal drugs for men.

From what period does a change in the hormonal balance of a man begin?

From about 25 years old, the level of testosterone produced by the male body begins to decline (1-1.5% per year). At a young age, such losses are negligible and the man does not notice them. But every year the level of testosterone is steadily falling and by the age of 40-45, the level of hormones in the male body is about 25-30% lower than the indicators at a young age. Changing the hormonal balance is an irreversible process of aging and it is impossible to turn it into sleep.

When are hormonal drugs prescribed?

A hormonal drug is prescribed by a doctor based on tests - they must confirm a low level of testosterone in the blood . In addition to the tests, the doctor must make sure that there are symptoms in the form of patient complaints about decreased sexual desire and ability, fatigue, weakness, poor mood, weight gain and other symptoms of low testosterone. Depending on the degree of hormonal deficiency, the doctor prescribes the medicine and the dose necessary to eliminate androgen deficiency.

Hormonal drugs are also prescribed for correction in the treatment of erectile dysfunction. Androgens can be included in an additional course of treatment and be used together with means to increase potency , and represent an independent course of treatment if the problem of ED is associated mainly with a decrease in sex hormones.

Types of hormones for men

Hormonal drugs are sold in tablets, capsules, gels, plasters, subcutaneous implants, and injections. Each method of hormone administration has its own characteristics.

Testosterone Capsules and Tablets

Capsules and tablets are well absorbed by the body, however, a quick release period does not allow to maintain a stable level of testosterone, which leads to the need for frequent use of the drug.

Testosterone Undecanoate - Andriol

Andriol 30 caps. 40 mg - 1200-1300 rub.

Andriol is a preoral testosterone drug that is absorbed from the digestive tract into lymph, while bypassing the liver. When taking the drug, it is difficult to achieve a stable concentration, because testosterone levels change abruptly: a sharp increase in hormone levels during absorption and decrease during excretion. In the body, testosterone undecanoate is converted into the active form of testosterone - dihydrotestosterone.

Advantages of Andriol:

  • does not have toxic effects on the liver;
  • not subject to aromatization - the conversion of testosterone to estrogen;
  • does not inhibit the own production of androgens (at moderate dosages);
  • lack of pronounced side effects.

Disadvantages of Andriol:

  • has low bioavailability;
  • requires daily use;
  • high price.

Application:

  • androgen deficiency;
  • eunuchoidism;
  • decreased libido;
  • decreased mental and physical activity;
  • mild forms of hypogonadism;
  • puberty delays in boys.
metiltestosteron

Methyltestosterone

Methyltestosterone is one of the very first synthetic testosterone preparations. Currently, the drug is banned for several reasons (it has a strong toxic effect on the liver) in many countries of the world.

Testosterone Gels and Ointments

Gels and ointments are quickly absorbed, hold the necessary level of testosterone well, but imply constant use, which does not exclude skin irritation (quite rarely).

Androgel

androgel 30 pack 2.5 mg - 2500 rubles.

The drug is produced in sachets with a dosage of 2.5 or 5 mg, 30 pieces per pack. Androgel is applied to clean skin once a day (preferably in the morning), usually in the area of ​​the shoulder, shoulder girdle, and abdomen. Absorbing gradually over 5 hours, the drug provides a constant physiological concentration of the hormone in the blood within the normal range for a healthy man. It is not recommended to take water procedures and have sexual contact up to 5 hours after the application of Androgel. The drug also increases estradiol levels in men within normal limits. After the cancellation of Androgel, testosterone levels return to baseline on the 4th day.

Testosterone patches

Patches are scrotal and wearable. Patches are an effective way to maintain testosterone levels. One patch is enough for about a day, after which it is necessary to replace the patch with a new one. A common side effect is irritation at the sites of skin contact with the patch (see testosterone patches for more information ).

Androderm

andoderm Available in a dose of 2.5 mg in a package of 30 and 60 pieces.

Contraindications:

  • Breast cancer
  • Prostate cancer
  • Hypercalcemia;
  • Kidney disease.

Use with caution when:

  • high blood pressure;
  • diseases of the heart, kidneys, liver.

зуд/покраснения в месте наклеивания пластыря, кожные высыпания и другие побочные эффекты, характерные для всех других форм тестостерона. Side effects: itching / redness at the place of application of the patch, skin rashes and other side effects characteristic of all other forms of testosterone.

Testosterone injection

One of the most common forms of testosterone administration in androgen deficiency. There are traditional injections (in the form of frequent use) and injections of prolonged action (one injection is enough for a long period). Long-acting injections are preferable, since they do not give such a sharp surge in the hormone, being released gradually and for a long time (up to 3 months). One of these long-acting injectable drugs based on testosterone undecanoate is Nebido, intended for intramuscular administration. Other injectable drugs: testosterone depot, Sustanon-250, testenat, etc.

sustanol-250 Sustanon-250

1 ampoule - 250-350 rubles.

Composition:

1 ampoule with 1 ml of an oil solution contains a mixture of testosterone propionate, decanoate, isocapronate and phenylpropionate.

Dosage administration:

Intramuscularly, deep into the muscle. The dosage is selected individually by the doctor, and usually is 1 ml 1 time in 3 weeks.

nebido Nebido

1 ampoule 250 mg / ml 4 ml - 4800-5500 rub.

Composition:

1 ampoule contains 1000 mg of testosterone undecanoate.

Dosage and administration:

Intramuscular injection of one Nebido ampoule is made 1 time in 10-14 weeks.

Subcutaneous implant

A subcutaneous cylinder implant is inserted under the skin under local anesthesia into the abdomen. A certain dose set by the attending physician is gradually released into the body. This implant allows you to maintain the required level of testosterone for 4-6 months. The disadvantage of this therapy is surgical intervention with characteristic complications (bruising, rejection).

Possible side effects of hormone replacement therapy:

  • increased risk of developing prostate cancer;
  • the occurrence of acne and oily skin;
  • androgenic alopecia ;
  • inhibition of the function of self-production of hormones and sperm.

In order to avoid possible side effects, hormone therapy with testosterone should be monitored by a doctor. Only a doctor can prescribe the necessary dose and method of administration of the drug. In no case do not self-medicate, relying on information obtained from various sources.

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